Skip to content
HER Foundation
  • Mother’s Area
  • Family & Friends
  • Healthcare Providers
  • Volunteers
  • Donate
FacebookTwitterSnapchatLinkedinPinterestYoutubeInstagram
  • Contact Us
  • Newsletter Signup
HER Foundation
  • Mother’s Area
  • Family & Friends
  • Healthcare Providers
  • Volunteers
  • Donate
  • Donate
  • Get Help Now
    • Immediate Help
    • Support Groups
    • Professional Referral Network
      • Find a Health Professional
      • Sign up for Referral Network
      • Update Referral Listing
    • Volunteer Network
      • Find a Volunteer
      • Sign up to Volunteer
      • Update Volunteer Information
    • Get Involved
    • Support Forum
  • About HG
    • About Hyperemesis
    • Do I Have Morning Sickness or HG?
    • Complications
      • Possible Complications
      • Malnutrition & Dehydration
      • Neurological Complications
      • Gastrointestinal Complications
    • Assess & Diagnose
    • Causes
    • Treatments
      • Common Treatments
      • Medications
      • Medication Strategies
      • Medication FAQs
      • Ondansetron (Zofran) Fetal Safety
      • Ondansetron (Zofran) Maternal Safety
      • Parenteral (Intravenous) Nutritional Therapy
      • Enteral (NG/PEG) Nutrition
      • Complementary Therapies
      • Bed Rest
    • Postpartum Recovery
      • Recovering from HG
      • Perinatal Mood & Anxiety Disorders (PMADs)
      • Post Traumatic Stress Disorder (PTSD)
  • Clinical Tools
    • HG Tools
    • HG Care App
    • HG Treatment Algorithm
    • HELP Score
    • HG Treatment Protocol
    • Weight Loss Calculator
  • Mother’s Area
  • Family & Friends
  • Volunteers
  • Healthcare Providers
  • Blog
    • Blog Posts
    • HER HG Stories
    • News
  • Store
  • Research
    • Our Collaborative Research
    • Current Research Opportunities
    • Genetics FAQ
  • Our Foundation
    • About HER
    • HER #HGVision
    • Support HER
    • Media Center
      • Press Info
      • HER Media Stories
      • Press Releases
    • Founders & Board of Directors
    • Mission and Goals
    • History
    • Global HG Documentary
    • LED Crisis Fund
September 3, 2022

What are the best medications to treat Hyperemesis Gravidarum?

The decision to take medication during pregnancy is difficult. However, chronic dehydration and malnutrition due to Hyperemesis Gravidarum (HG) carry risks that may be greater than the tiny possible risks of ondansetron or other medications.

pregnant woman taking medication

Ondansetron (Zofran) is a Class B serotonin antagonist. This class of medication is found to improve symptoms in > 80% of women.

Tips For Taking Ondansetron

  • lasts about 6 hours
  • take with a daily stool softener
  • take on a strict schedule
  • dose: 4 mg every 3-6 hours OR 8 mg every 6 hours
  • maximum 32 mg throughout the day

Routes For Taking Ondansetron

  • Tablet (oral)
  • ODT (oral or vaginal)
  • Compounded
  • Subcutaneous pump
  • IV


More To Know About Ondansetron

If you have pre-existing medical conditions (diabetes, heart disease, etc.), a history of medication reactions, or are a smoker, please inform your physician before taking these medications.

Often effective in patients who have multiple triggers (smell, motion, etc.), a history of hormone sensitivity, and/or moderate to severe vomiting.

If a patient has a history of HG that responded to serotonin antagonists, it should be considered as a first line drug to minimize symptom severity.

Dosing throughout pregnancy may prevent relapse or stabilize symptoms.

Avoid use with other serotonin antagonists (e.g. SSRI’s, antidepressants) to prevent serotonin syndrome.

More common side-effects: Headache, mild/moderate (reversible) liver function test abnormalities, constipation*, diarrhea

Common HG Medications
Save Money on Zofran
Zofran Safety Statement
Donate to Improve Treatment and Education

GET INVOLVED

  • Participate in HG research.
  • Become an advocate.
  • Make a gift to the HER Foundation.
  • Share your story and support other HG moms.
  • Become a HER Foundation volunteer.
  • Blog about HG and show support for HER.
  • Share resources with local health professionals and hospitals.

©2022 HER Foundation. All rights reserved.

Posted in HG Management, What is HG
Share this

Recent Posts

  • HG Reality 2023
  • AmazonSmile charitable giving program ends
  • ICHG 2024
  • HER Research Surveys
  • Impact Report: 2021-2022

Categories

  • 1 Mom 2 Many
  • 1 Mom Blog
  • Books
  • Events
  • Fundraising
  • General
  • HERstory
  • HG Awareness
  • HG Awareness Items
  • HG Management
  • Mom Stories
  • Networking
  • New Products
  • News
  • Partners
  • Press Releases
  • Recommended Books
  • Research
  • Resources
  • Store
  • T-shirts
  • Uncategorized
  • What is HG
iGive.com

In Memoriam


To honor your loved one, please enter their name(s) here.

Take a Poll

Get Involved

Let’s make HG history! Be part of the progress by supporting the HER Foundation and helping us raise the voice of mothers around the world! Together, we can give mothers and babies a healthier future.

Donate
Newsletter Signup
HER_foundation_white

info@hyperemesis.org

+1 888-264-2914

Who We Help

  • Mother’s Area
  • Family & Friends
  • Healthcare Providers
  • Volunteers
  • Donate

Navigate

  • Home
  • About HG
  • Our Foundation
  • Research
  • Blog
  • Store
  • Sitemap

Translate

HER Foundation • Privacy Policy • Disclaimer

Website by Yoko Co

feedback_caps.png

Donate to sustain HER’s important work helping mothers and babies survive HG!

 

Donate

Scroll To Top
© HER Foundation 2022. No part of the materials available through the hyperemesis.org site may be copied, photocopied, reproduced, translated or reduced to any electronic medium or machine-readable form, in whole or in part, without prior written consent of the HER Foundation. Any other reproduction in any form without the permission of the HER Foundation is prohibited. All materials contained on this site are protected by United States copyright law and may not be reproduced, distributed, transmitted, displayed, published or broadcast without the prior written permission of the HER Foundation.