ICHG 2024 Presentations

Dr. Marlena Fejzo discusses genetic research on hyperemesis gravidarum (HG). The study focuses on maternal and fetal genes, highlighting GWAS and exome sequencing approaches. In addition to key genes including GDF15 and IGFBP7, new genetic associations are identified with implications for appetite, insulin signaling, and brain function. The evolutionary context of nausea and vomiting is also discussed. The research aims to improve prediction, diagnosis, and treatment of HG through insights into genetic factors contributing to HG.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Sir Stephen O'Rahilly, MD

GDF15 and the Pathogenesis of Pregnancy Sickness

Presentation Overview

Professor Stephen O’Rahilly from the University of Cambridge discussed the collaborative work which discovered that GDF15 plays a major role in the pathophysiology of Hyperemesis Gravidarum. GDF15, a hormone of the TGF beta family, is made by the fetal component of the placenta and its circulating levels are higher in women with HG than in matched controls. Women’s sensitivity to the nauseating effects of this hormone vary in a way that is influenced by prior exposure to the hormone. Women with lower levels of GDF15 before pregnancy are more susceptible to developing HG. O’Rahilly’s lab had previously shown that metformin , a commonly used and largely safe drug elevates circulating levels of GDF15. In future trials, designed in partnership with sufferers, women with a history of HG will receive metformin or placebo prior to a planned pregnancy in order to determine whether the drug can reduce the incidence and/or severity of HG.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Dr. Andrew Housholder, MD, FACEP

The Morning Sickness Clinic: A New Approach to Care

Presentation Overview

Join Dr. Andrew Housholder as he discusses the Morning Sickness and HG Clinic's new approach to treating hyperemesis gravidarum. Learn about the clinic's history, patient demographics, and treatment methods. Discover how early and aggressive treatment can significantly reduce hospitalizations and improve patient outcomes. The video also highlights the importance of medication management, data collection, and ongoing education to advance HG care.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Dr. Marc Vaudel, PhD

Contribution of Maternal, Paternal, and Fetal Genes to HG and Adverse Outcomes

Presentation Overview

Dr. Marc Vaudel presents an in-depth analysis of his research on nausea, vomiting, and hyperemesis during pregnancy. Using a large cohort study from Norway, Dr. Vaudel examines the genetic and metabolic factors affecting maternal and fetal health. This presentation covers findings on placental growth, genetic variants, and their implications for women's health, emphasizing the need for collaboration and effective communication in the scientific community.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Dr. Joanne Lancaster, PhD

NGM120, a GFRAL Antagonist Antibody, for Investigation of Safety, Tolerability and Efficacy in Hyperemesis Gravidarum

Presentation Overview

Joanne Lancaster, VP of Project Team Development at NGM Biopharmaceuticals, presents on NGM120, a GFRAL antagonist antibody intended for the investigation of safety, tolerability, and efficacy in hyperemesis gravidarum. Lancaster elaborates on the preclinical data, clinical study design, and the potential of NGM120 to address severe nausea and vomiting in pregnancy. She also details the EMERALD study, which is set to launch in both Australia and the United Kingdom, focusing on the antibody's action mechanism, safety assessments, and efficacy endpoints. Audience members pose insightful questions, fostering a robust discussion on the implications and potential challenges of the study.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Dr. Tito Borner, PhD

Central Mechanisms of Nausea and Emesis: Insights from Preclinical Models

Presentation Overview

Access Slides and Video

Dr. Aimee Brecht-Doscher, MD

Difficult Cases Roundtable Discussion

Presentation Overview

Healthcare professionals, Dr. Brecht-Doscher, MD, Dr. Housholder, MD, and Dr. Trovik, MD, dive into the intricacies of managing hyperemesis gravidarum (HG). The session covers detailed case studies, showcasing the evolution of care and response to treatments, from medication adjustments to the consideration of nutritional needs. Experts discuss the importance of proactive and timely interventions, as well as the potential use of innovative treatments like Olanzapine and steroids. Valuable insights into patient care and clinical strategies are shared, providing a comprehensive understanding of HG management for both new and experienced practitioners.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Dr. Amy Valent, DO, MCR

Nutrition and Perinatal Health

Presentation Overview

Dr. Amy Valent, an associate professor from Oregon Health and Sciences University and a maternal fetal medicine specialist, delves into the critical aspects of maternal nutrition, placental biology, and diabetes care during pregnancy. Dr. Valent emphasizes the significance of nutritional access and preconception health, highlighting the complex interplay of diet, lifestyle behaviors, and metabolic health in pregnancy outcomes. Discover the fascinating connections between preconception nutrition, fetal development, and long-term health, and explore practical applications and guidelines for improving nutritional care during pregnancy.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Kimber W. MacGibbon, RN, BSN, MSGH

Legislated Improvements in HG Care: Texas HHS Experience

Presentation Overview

Access Slides and Video

Eileen O’Brien, PhD

Dietary Intakes Pre- and Post-Intervention: Results from The IRIS Clinic Study

Presentation Overview

Access Abstract and Video

Ellie Lewis

Hyperemesis Gravidarum and Cannabis Use in an International Sample of Pregnant People

Presentation Overview

Ellie Lewis, an undergraduate student at Johns Hopkins University, explores the use of cannabis to treat hyperemesis gravidarum during pregnancy. Her presentation unveils the results of an international survey, examining cannabis effectiveness compared to prescription medications and discussing demographic disparities in its use. Discover crucial insights into maternal and child health outcomes associated with cannabis use during pregnancy.

Presented at the International Colloquium of Hyperemesis Gravidarum (ICHG) 2024 conference in Ventura, California.

Access Slides and Video

Iqra Khan, BSC, IBCLC

Transforming Hyperemesis Gravidarum Care: from Hospital to the Home

Presentation Overview

Access Slides and Video

Margaret Riley, JD

Advancing Clinical Research in the Pregnant Population

Presentation Overview

Access Slides and Video

Charlotte Howden

The CronShaw Family’s HG Experience

Presentation Overview

Access Slides and Video

Sarit Kang-Auger

Hyperemesis Gravidarum and Risk of Severe Maternal and Fetal Morbidity Retrospective Cohort Study

Presentation Overview

Access Slides and Video

Elieen O'Brien, PhD

Nutrition and HG Breakout Session

Presentation Overview

Access Video

Q&A and Awards

Q&A for Riley, MacGibbon, Fraser and Howden and Awards

Q&A for Riley, MacGibbon, Fraser, and Howden 16 x 9

Presentation Overview

Access Video

Your Voice at ICHG

"I survived because of other women. Not doctors, not specialists. But because other women had formed communities of support for each other that offered the tools, the information, the 'you are not alone' validation to enable us to fight for our health care, an accurate diagnosis and the right medication."

Petra
Surrey, UK

"When I found out I was pregnant, it was the happiest day of my life and I couldn't wait for my pregnancy journey to start. Little did I know that it would be the most horrendous experience I would ever encounter. At just 7 weeks pregnant, I would find myself vomiting every half an hour to an hour, I couldn't eat or keep any kind of fluids down. By 8 weeks pregnant I was hospitalized with severe dehydration and put on IV fluids."

Lauren
Kent, England

The International Collaboration for Hyperemesis Gravidarum Research in 2024 provided a unique opportunity for healthcare professionals and researchers to connect and share new knowledge about Hyperemesis Gravidarum.

Read selected abstracts.

Below you can find videos and slides from ICHG presentations!

Note: The small fee will help cover the platform fee for the video hosting. Not all presentation/slides are available to rewatch. A full list of speakers at ICHG 2024 is here.

Search by

Dr. Marlena Fejzo, PhD

The Search for a Cause

Sir Stephen O'Rahilly, MD

GDF15 and the Pathogenesis of Pregnancy Sickness

Dr. Andrew Housholder, MD, FACEP

The Morning Sickness Clinic: A New Approach to Care

Dr. Marc Vaudel, PhD

Contribution of Maternal, Paternal, and Fetal Genes to HG and Adverse Outcomes

Dr. Joanne Lancaster, PhD

NGM120, a GFRAL Antagonist Antibody, for Investigation of Safety, Tolerability and Efficacy in Hyperemesis Gravidarum

Dr. Tito Borner, PhD

Central Mechanisms of Nausea and Emesis: Insights from Preclinical Models

Dr. Aimee Brecht-Doscher, MD

Difficult Cases Roundtable Discussion

Dr. Amy Valent, DO, MCR

Nutrition and Perinatal Health

Kimber W. MacGibbon, RN, BSN, MSGH

Legislated Improvements in HG Care: Texas HHS Experience

Eileen O’Brien, PhD

Dietary Intakes Pre- and Post-Intervention: Results from The IRIS Clinic Study

Ellie Lewis

Hyperemesis Gravidarum and Cannabis Use in an International Sample of Pregnant People

Iqra Khan, BSC, IBCLC

Transforming Hyperemesis Gravidarum Care: from Hospital to the Home

Margaret Riley, JD

Advancing Clinical Research in the Pregnant Population

Charlotte Howden

The CronShaw Family’s HG Experience

Sarit Kang-Auger

Hyperemesis Gravidarum and Risk of Severe Maternal and Fetal Morbidity Retrospective Cohort Study

Elieen O'Brien, PhD

Nutrition and HG Breakout Session

Q&A and Awards

Q&A for Riley, MacGibbon, Fraser and Howden and Awards

Your Voice at ICHG

Get Involved

Who We Help

Navigate

Translate